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Term Definition
absorptionThe process the body uses to move elements from the outside world into the blood and other tissues. Food is absorbed through the stomach and intestines. Nicotine is absorbed through the lungs.

abstinenceThe conscious choice not to use drugs. The term "abstinence" usually refers to the decision to end the use of a drug as part of the process of recovery from addiction.

acetaldehydeThe metabolite that results when alcohol dehydrogenase breaks down alcohol in the body.

acetylcholineA neurotransmitter. Acetylcholine is used by spinal cord neurons to control muscles and by many other neurons in the brain as well. Nicotine binds to one type of acetylcholine receptor.

action potentialThe electrical part of a neuron's two-part, electrical-chemical message. An action potential consists of a brief pulse of electrical current that travels along the axon to relay messages over long distances.

acute effectsThe short-term effects of a drug. Acute effects are those that people feel shortly after they ingest a drug and are under its influence (e.g., while they are intoxicated).

adaptive behaviorsUseful behaviors we acquire as we respond to the world around us. Adaptive behaviors help us get the things we want and need for life.

addictionA brain disorder characterized by the loss of control of drug-taking behavior, despite adverse health, social, or legal consequences to continued drug use. Addiction tends to be chronic and to be characterized by relapses during recovery.

addictive drugsDrugs that change the brain, change behavior, and lead to the loss of control of drug-taking behavior.

adenosineA neurotransmitter that binds to the adenosine receptor. Caffeine is an adenosine antagonist and prevents adenosine from binding with its receptor.

adrenal glandA small gland in the body that releases a variety of hormones that help us deal with stress. Two of these hormones, epinephrine and norepinephrine, are also part of the flight-or-fight response. Cocaine sharply increases the levels of these hormones in the body.

agonistA chemically simple, but psychoactively complex drug commonly used in many beverages. Alcohol is a depressant drug with significant liability for abuse and addiction.

alcohol dehydrogenaseThe enzyme found mainly in the liver and stomach that breaks down (metabolizes) alcohol.

Alcoholics AnonymousOne of the earliest forms of addiction treatment in the United States, AA developed the 12-step approach to assisting recovery from alcohol addiction (alcoholism). Several other anonymous groups have adapted the 12-step approach to help people recover from addiction to other drugs (e.g., Narcotics Anonymous, Cocaine Anonymous, Pot Smokers Anonymous).

alveoliTiny, balloon-like air sacks in the lungs. Alveoli are designed to allow oxygen to pass rapidly into the blood and are also efficient at absorbing inhaled drugs.

Alzheimer's diseaseA degenerative disease in which neurons of the brain die, leading to the loss of the ability to think, learn and remember (dementia).

amino acidsSmall chemical compounds that are the building blocks of proteins.

amphetaminesStimulant drugs whose effects are very similar to cocaine.

analgesicsDrugs that relieve pain.

analogsDrugs whose chemical structures have been slightly modified from a parent compound. There are many analogs to morphine or to LSD. See Designer drug.

anandamideThe endogenous neurotransmitter that binds to the cannabinoid receptor.

anesthesiaThe loss of sensation, primarily to pain, often accompanied by the loss of consciousness.

anesthetic gasesGaseous drugs that produce loss of sensation and consciousness.

antagonistA chemical that binds to a receptor and blocks it, producing no response, and preventing agonists from binding, or attaching, to the receptor. Antagonists include caffeine and naloxone.

assessmentThe diagnostic process in which a professional examines a drug user to determine the extent of the person's drug use, whether he or she is addicted, and what type of treatment might be most effective.

Special Thanks:
Addiction Studies Program - Wake Forest University School of Medicine
False Messengers: How Addictive Drugs Change the Brain by David Friedman, PhD, and Sue Rusche, Harwood Academic Publishers, Amsterdam, The Netherlands, 1999. [www.addictionstudies.org]