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Term Definition
deconditionThe unlearning of classically conditioned responses. Helping addicts identify and neutralize the cues of triggers they developed while they were addicted.

dendritesThe branches that reach out from a neuron's cell body to receive messages from the axon terminals of other neurons.

denialUnconsciously refusing to admit that someone is addicted. Denial occurs among addicts themselves and among those who are close to them.

dentate gyrusA key part of the hippocampus that contains one of the highest concentrations of cannabinoid receptors in the brain.

deoxyribonucleic acid(DNA) The chemical compound that makes up genes.

depressantsDrugs that relieve anxiety and produce sleep. Depressants include barbiturates, benzodiazepines, and alcohol.

designer drugAn illegally manufactured chemical whose molecular structure is altered slightly from a parent compound to enhance specific effects. Examples include DMT, DMA, DOM, MDA and MDMA (ecstasy).

detoxificationThe process of removing a drug from the body. This is the initial period addicts must go through to become drug-free. Withdrawal symptoms appear early during this process. Depending on the drug, detoxification lasts for a few days to a week or more.

diversionTaking legally prescribed medications (e.g., methadone, tranquilizers) and selling them illegally.

DMAA hallucinogenic "designer drug" with psychedelic properties.

DMTA hallucinogenic "designer drug" with psychedelic properties.

DNADeoxyribonucleic acid (DNA) The chemical compound that makes up genes.

DOMA hallucinogenic "designer drug" with psychedelic properties.

dopamineThe neurotransmitter that produces feelings of pleasure when released by the brain reward system.

dopamine transporterA structure that straddles the cell membranes of axon terminals of dopamine-releasing neurons and rapidly removes dopamine from the synapse.

double-blind trialsStudies of an experimental drug in which neither patient nor doctor knows whether the patient is receiving the experimental drug or some alternative (which might be a placebo if no treatment already exists).

DronabinolThe generic name of synthetic THC.

drug abuseUsing illegal drugs; using legal drugs inappropriately. The repeated, high-dose, self-administration of drugs to produce pleasure, to alleviate stress, or to alter or avoid reality (or all three).

drug treatmentA combination of detoxification, psychosocial therapy and, if required, skill acquisition to help people recover from addiction.

drug-free treatmentA approach to helping addicts recover from addiction without the use of medication.

dynorphinsPeptides with opiate-like effects that are made by neurons and used as neurotransmitters; one of the endogenous opiods that binds to opiate receptors.

Special Thanks:
Addiction Studies Program - Wake Forest University School of Medicine
False Messengers: How Addictive Drugs Change the Brain by David Friedman, PhD, and Sue Rusche, Harwood Academic Publishers, Amsterdam, The Netherlands, 1999. [www.addictionstudies.org]