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Term Definition
LAAMA very long-lasting opiate agonist recently approved for the treatment of opiate addiction.

ligandAny chemical that binds to a receptor. Ligands may be agonists or antagonists.

limbic systemA set of brain structures that generates our feelings, emotions, and motivations. It is also important in learning and memory.

localization of functionA principal of brain organization that states that specific places (circuits) in the brain carry out specific functions.

locus coeruleusA group of neurons (nucleus) that is the source of all of the neurotransmitter norepinephrine in the brain.

long term memoryEnduring memories about things, places, and events.

long-term effectsThe effects seen when a drug is used repeatedly over weeks, months, or years. These effects may outlast drug use.

long-term memory circuitThe brain circuit, including the cerebral cortex and hippocampus, which enables the brain to lay down and store memories in the cortex.

LSDAn hallucinogenic drug that acts on the serotonin receptor.

Special Thanks:
Addiction Studies Program - Wake Forest University School of Medicine
False Messengers: How Addictive Drugs Change the Brain by David Friedman, PhD, and Sue Rusche, Harwood Academic Publishers, Amsterdam, The Netherlands, 1999. [www.addictionstudies.org]