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Term Definition
open-label studyA study in which both doctor and patient know that patients are receiving an experimental drug and what that drug is.

operant conditioningAn unconscious form of learning in which a behavior is linked to a specific stimulus through a process of reinforcement.

opiate receptorsReceptors that recognize both opiates and endogenous opioids. When activated, they slow down or inhibit the activity of neurons on which they reside.

OpiatesAny of the psychoactive drugs that originate from the opium poppy or that have a chemical structure like the drugs derived from opium. Such drugs include opium, codeine, and morphine (derived from the plant), and hydromorphone (Dilaudid), methadone, and meperidine (Demerol), which were first synthesized by chemists.

OpioidAny chemical that has opiate-like effects; commonly used to refer to endogenous neurochemicals that activate opiate receptors.

organic solventsOne class of inhalants that includes substances such as gasoline, paint thinner, and glue. Organic solvents are neurotoxic because they dissolve fatty substances, including the axon's myeline sheath.

outpatient treatmentNonresidential treatment for drug addiction. Patients live at home, often work, and come to a clinic for treatment.

overdoseThe condition that results when too much of a drug is taken, making a person sick or unconscious and sometimes resulting in death.

Special Thanks:
Addiction Studies Program - Wake Forest University School of Medicine
False Messengers: How Addictive Drugs Change the Brain by David Friedman, PhD, and Sue Rusche, Harwood Academic Publishers, Amsterdam, The Netherlands, 1999. [www.addictionstudies.org]