GI Web Glossary
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Term Definition
DOMA hallucinogenic "designer drug" with psychedelic properties.

dopamineThe neurotransmitter that produces feelings of pleasure when released by the brain reward system.

dopamine transporterA structure that straddles the cell membranes of axon terminals of dopamine-releasing neurons and rapidly removes dopamine from the synapse.

double-blind trialsStudies of an experimental drug in which neither patient nor doctor knows whether the patient is receiving the experimental drug or some alternative (which might be a placebo if no treatment already exists).

DronabinolThe generic name of synthetic THC.

drug abuseUsing illegal drugs; using legal drugs inappropriately. The repeated, high-dose, self-administration of drugs to produce pleasure, to alleviate stress, or to alter or avoid reality (or all three).

drug treatmentA combination of detoxification, psychosocial therapy and, if required, skill acquisition to help people recover from addiction.

drug-free treatmentA approach to helping addicts recover from addiction without the use of medication.

dynorphinsPeptides with opiate-like effects that are made by neurons and used as neurotransmitters; one of the endogenous opiods that binds to opiate receptors.

Ecstasy(MDMA) A chemically modified amphetamine that has hallucinogenic as well as stimulant properties.

enablingThings that people who are close to addicts do unconsciously that either encourage, or at least do not interfere with, the addict's drug use.

endogenousSomething produced by the brain or body.

endorphinsPeptides with opiate-like effects that are made by neurons and used as neurotransmitters; one of the endogenous opioids that binds to opiate receptors.

enkephalinsPeptides with opiate-like effects that are made by neurons and used as neurotransmitters; one of the endogenous opioids that binds to opiate receptors.

enzymeA large molecule that living organisms use to facilitate the transition from one form of a chemical to another. Enzymes are used to build, modify, or break down different molecules.

EtherAn inhalant. Ether was one of the first anesthetics to be used in surgery, but has been replaced by more effective, safer anesthetics.

euphoriaIntense pleasure. Drug-induced euphoria is a "rush" or pleasurable feeling. It is caused by the release of the neurotransmitter, dopamine, within the brain reward system.

excitatory neurotransmitterA neurotransmitter that acts to elicit an action potential or make it more likely that one will be elicited.

explicit memoryMemories derived from conscious learning, using our senses and attention to store information about what is in the world and where and when events have occurred.

fight-or-flight responseAn automatic response of our body that prepares us to act to save ourselves when we become excited or scared.

free willOur ability to make choices and decisions that are not under the control of outside forces or prior causes.

GABA(gamma-aminobutyric acid) The major inhibitory neurotransmitter in the brain.

gamma-aminobutyric acid(GABA) The major inhibitory neurotransmitter in the brain.

geneStrands of DNA that contain the blueprint of all the molecules that make up our bodies.

glial cellsTiny brain cells that support neurons by performing a variety of "housekeeping" functions in the brain.

Special Thanks:
Addiction Studies Program - Wake Forest University School of Medicine
False Messengers: How Addictive Drugs Change the Brain by David Friedman, PhD, and Sue Rusche, Harwood Academic Publishers, Amsterdam, The Netherlands, 1999. [www.addictionstudies.org]